We have identified and are developing several potent small molecule inhibitors of the NLRP3 Inflammasome. Our drugs can be taken orally and block NLRP3 inflammasome activation very precisely. By selectively targeting the NLRP3 our therapies have the potential to stop harmful, disease causing, inflammation while allowing beneficial inflammation and minimising side effects.
The following pipeline describes the future plans for these candidate drugs.
Inzomelid is a potent, selective, brain-penetrant NLRP3 inhibitor that is currently in Phase I trials.
Somalix is a potent, selective, peripherally restricted NLRP3 inhibitor that is currently in Phase I trials.
Our 3rd candidate is a potent, selective, peripherally restricted NLRP3 inhibitor.
Inflazome is exploring tissue-specific inhibitors for Gastro-Intestinal (IBD, Crohn’s) and Dermatological (Psoriasis, Atopic Dermatitis) diseases.
Inflazome has partnered with the Michael J Fox Foundation for Parkinson’s Research, who provided funding in excess of US$1 million to support the development of a brain imaging probe for patient diagnosis and the clinical development of drugs to treat neurodegenerative diseases.
We are open to partnering with Biotech and Pharma companies with excellent clinical development and marketing capabilities to.
NLRP3 inhibitors have the potential to change the lives of millions of people. Inhibiting NLRP3 at the key point of inflammation may help slow the progression of diseases such as Parkinson’s and could help prevent life threatening cardiovascular events.
Chief Medical Officer
Dedicated to Inflammation
Learn how the inflammation cycle leads to some of the worlds most chronic and debilitating dieseaes