Inflazome responds to the CANTOS trial in The New England Journal of Medicine

Inflazome responds to the CANTOS trial in The New England Journal of Medicine

Dublin (IE), Cambridge (UK) | 11 January 2018: Inflazome's CSO Dr Luke O'Neill and CEO Dr Matt Cooper publish a letter to the editor in The New England Journal of Medicine (NEJM) today, commenting on the Canakinumab Antiinflammatory Thrombosis Outcome Study (CANTOS) by Ridker et al. that found reduced inflammation was associated with reduced cardiovascular risk.

To the Editor: In CANTOS, blocking interleukin-1β reduced the incidence of atherothrombosis and nonfatal stroke, and an additional analysis showed that patients who received the 300-mg dose of canakinumab had a total cancer mortality that was lower by 51% than those who received placebo and a lung-cancer mortality that was lower by 77%.1 The incidence of fatal infection was nearly twice as high in the pooled canakinumab groups as in the placebo group, a finding similar to that observed with the interleukin-1 receptor antagonist anakinra.2 The accompanying editorial by Harrington3 discussed the safety risk of interleukin-1β blockade.

Interleukin-1β is driven by multiple inflammasomes. As an alternative to inhibition of interleukin-1β, precise inhibition of a single inflammasome, NLRP3, is likely to be safer. NLRP3 is implicated in diseases of aging, such as atherosclerosis and neurodegenerative disorders. Selective NLRP3 inhibition will leave other inflammasomes to respond to infection. In addition, at the onset of severe infection, an orally available small molecule could be withdrawn, whereas canakinumab cannot. NLRP3 activation also drives interleukin-18, the clinical targeting of which is also safe.4

CANTOS has advanced our understanding of the clinical relevance of interleukin-1β and the NLRP3 inflammasome. This trial will drive the development and commercialization of an entirely new class of drugs.

References:

  1. Ridker PM, MacFadyen JG, Thuren T, et al. Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial. Lancet2017;390:1833-1842

  2. Cabral VP, Andrade CA, Passos SR, Martins MF. Hkerberg YH. Severe infection in patients with rheumatoid arthritis taking anakinra, rituximab, or abatacept: a systematic review of observational studies. Rev Bras Reumatol Engl Ed 2016;56:543-550

  3. Harrington RA. Targeting inflammation in coronary artery disease. N Engl J Med2017;377:1197-1198

  4. McKie EA, Reid JL, Mistry PC, et al. A study to investigate the efficacy and safety of an anti-interleukin-18 monoclonal antibody in the treatment of type 2 diabetes mellitus. PLoS One 2016;11:e0150018-e0150018
     

Read the full article in NEJM here.

Inflazome Appoints Renowned Harvard Cardiologist to its Scientific Advisory Board

Inflazome Appoints Renowned Harvard Cardiologist to its Scientific Advisory Board

Prof. Paul Ridker joins Inflazome’s Scientific Advisory Board

Dublin (IE), Cambridge (UK) | 04 January 2018: Inflazome Ltd, a biotech company developing small molecule drugs that stop harmful inflammation, today announces the appointment of Prof. Paul Ridker to Inflazome’s Scientific Advisory Board. Prof. Ridker is a leading scientific expert in cardiovascular disease and is renowned for his work on inflammation and its role in heart disease. Medical researcher and the Eugene Braunwald Professor of Medicine at Harvard University, Prof. Ridker also directs the Center for Cardiovascular Disease Prevention at the Brigham and Women’s Hospital in Boston, Massachusetts.

Dr. Matt Cooper, Co-founder and CEO of Inflazome Ltd, commented: “We’re delighted to welcome Prof. Paul Ridker to Inflazome’s Scientific Advisory Board. Prof. Ridker is a world-renowned cardiologist who has clinically validated the link between inflammation and heart disease. His work has been instrumental in understanding biological mechanisms of heart disease and developing therapeutic approaches to treat the disease. At Inflazome, we are dedicated to improving lives by delivering new medicines that stop inflammation. Prof. Ridker’s scientific and medical expertise will be invaluable to the development and progress of science as we expand our pipeline of novel inflammasome inhibitors into the cardiovascular disease space. Following the recent appointments of Prof. Frances Balkwill and Dr. David Morris, Prof. Ridker’s appointment complements and augments the strength of our Scientific Advisory Board, whose contributions will help us achieve our mission; to improve lives by delivering new medicines that stop harmful inflammation.”

Paul M. Ridker, MD, Brigham and Women’s Hospital, Boston, commented: “I am pleased to be joining Inflazome’s Scientific Advisory Board. I believe the NLRP3 inflammasome plays a critical role in driving inflammation associated with cardiovascular disease and that orally bioavailable inhibitors may have the potential to make a significant impact on heart disease patients.  I look forward to contributing my knowledge and expertise to help achieve this goal.”

About Prof. Paul Ridker

Prof. Paul M. Ridker MD, MPH, FACC is a Eugene Braunwald Professor of Medicine at Harvard Medical School and serves as a Director of the Center for Cardiovascular Disease Prevention at Brigham and Women's Hospital. Prof. Ridker specialised in atherosclerosis and cardiovascular disease including the role of inflammation in the disease process and the role of CRP.

Prof. Ridker’s particular areas of interest involve molecular and genetic determinants of hemostasis, thrombosis, and inflammation with a focus on "predictive medicine", early disease diagnosis, and the underlying causes and prevention of acute coronary syndromes. His research efforts are primarily supported by RO1 research grants from the National Heart, Lung, and Blood Institute (NHLBI), a Distinguished Clinical Scientist Award from the Doris Duke Charitable Foundation, and through philanthropic research grants from the Leducq Foundation and the Donald W Reynolds Foundation.

Prof. Ridker has been the recipient of a Clinician Scientist Award (1992-1997), an Established Investigator Award (1997-2002), and a Distinguished Scientist Award (2013) from the American Heart Association. His pioneering work on inflammation, CRP, and atherothrombosis, was also recognized by Time Magazine who named him among America's Ten Best Researchers in Science and Medicine in 2001 and as one of the "Time 100" in 2004.

In addition to his work in cardiovascular epidemiology, Prof. Ridker has been the Principal Investigator or Study Chairman of several multinational clinical trials including PREVENT, PRINCE, Val-MARC, LANCET, JUPITER, SPIRE-1, SPIRE-2, as well as the Canakinumab Anti-Inflammatory Thrombosis Outcomes Study (CANTOS) and the NHLBI-funded Cardiovascular Inflammation Reduction Trial (CIRT), both designed to directly test the inflammatory hypothesis of atherothrombosis. Prof. Ridker is also Trial Chairman of PROMINENT, an ongoing study of triglyceride reduction among patients with diabetes.

Prof. Ridker is the author of over 800 original articles and 5 textbooks related to cardiovascular medicine. A frequent invited lecturer at national and international conferences, he is also a member of multiple editorial boards and co-inventor on patents filed by the Brigham and Women's Hospital that relate to the use of inflammatory biomarkers in cardiovascular disease.

 

Members of Inflazome’s Board of Directors include:

•                Dr. Manus Rogan, Chair, Managing Partner, Fountain Healthcare Partners

•                Dr. Matt Cooper, Co-founder & Chief Executive Officer

•                Florent Gros, Managing Director, Novartis Venture Fund

•                Prof. Luke O’Neill, Co-founder & Chief Scientific Officer

•                Dr. Dhavalkumar Patel, Independent Director

Members of the Inflazome’s Scientific Advisory Board include:

•                Prof. Luke O’Neill, Trinity College Dublin

•                Prof. Frances Balkwill, Queen Mary University of London

•                Dr. Douglas Golenbock, University of Massachusetts Medical School

•                Dr. Veit Hornung, Ludwig Maximilian University of Munich

•                David Morris, MD, Novartis Venture Fund

•                Prof. Mihai G. Netea, Nijmegen University

•                Paul M. Ridker, MD, Brigham and Women’s Hospital

About Inflazome

Utilising the scientific expertise of our founders and advisors, Inflazome is leading the way in developing orally available drugs to address clinical unmet needs in inflammatory diseases by targeting the inflammasome, which is now thought to drive many chronic inflammatory conditions.

Headquartered in Dublin, Ireland, Inflazome was founded by leading academics Prof. Matt Cooper, The University of Queensland (Australia) and Prof. Luke O’Neill, Trinity College Dublin (Ireland), following a highly productive joint collaboration. inflazome.com

Founding investors are Fountain Healthcare Partners (Dublin, Ireland) and Novartis Venture Fund (Basel, Switzerland).

About Fountain Healthcare Partners

Fountain Healthcare Partners is a life science focused venture capital fund with €176 million ($200 million) under management. Within the life science sector, specific areas of interest to Fountain include specialty pharma, medical devices, biotechnology and diagnostics. The firm deploys the majority of its capital in Europe, with the balance in the United States. Fountain’s main office is in Dublin, Ireland, with a second office in New York. fh-partners.com 

About The Novartis Venture Fund

The Novartis Venture Fund (NVF) manages over $700 million in committed capital. NVF invests in companies that have the potential to change a core therapeutic field or explore new business areas that will be critical to patient care. NVF’s primary interest is in the development of novel therapeutics and platforms as well as medical devices, diagnostics, and delivery systems. The Funds invest for financial objectives at all stages, but prefers to invest in the early-stages of company development. With investment professionals located in Basel, Switzerland and Cambridge, MA the team has extensive experience in pharmaceutical R&D and venture capital. nvfund.com

 

Contacts:

Inflazome

Dr. Jeremy Skillington | VP Business Development | j.skillington@inflazome.com | +353 1 679 8591
Ruth Neale | Communications and Outreach |r.neale@inflazome.com  | +44 1223 751549

Inflazome's CSO wins Trinity Provost Innovation Award

Inflazome's CSO wins Trinity Provost Innovation Award

Dublin, Ireland – 28 November, 2017 - Researchers at Trinity College Dublin were acknowledged for their innovative research and entrepreneurship at the Trinity Innovation Awards 2017 special awards ceremony last night [November 27th, 2017].

The highest accolade, the Provost Innovation Award went to Inflazome’s Chief Scientific Officer and TCD Professor of Biochemistry, Luke O’Neill for his outstanding contribution to innovation throughout his career. Read the full story here.

 

Inflazome Appoints Renowned Scientific, Industry & Clinical Experts

Inflazome Appoints Renowned Scientific, Industry & Clinical Experts

-      Prof. Frances Balkwill, OBE FMedSci, and Dr. David Morris join Inflazome’s Scientific Advisory Board

-      Dr. Dhavalkumar Patel, Executive Vice President and Chief Scientific Officer of UCB, appointed to Inflazome’s Board of Directors

Dublin (IE), Cambridge (UK) | 28 November 2017: Inflazome Ltd, the biotech company developing small molecule drugs that stop harmful inflammation, today announces the appointment of three leading scientific, industry & clinical experts to its Scientific Advisory Board and Board of Directors.

Prof. Frances Balkwill, OBE, FMedSci, a scientific expert in cancer biology joins Inflazome’s Scientific Advisory Board from Queen Mary University of London, where she leads the Centre for Cancer and Inflammation. With a clinical, scientific background and extensive operational experience, Dr. David Morris also joins the Scientific Advisory Board from Novartis Venture Fund. Furthermore, Dr. Dhavalkumar Patel, Executive Vice President and Chief Scientific Officer of global biopharma company UCB, based in Brussels, Belgium, has been appointed to Inflazome’s Board of Directors as an Independent Director, following a distinguished career in Novartis.

Dr. Matt Cooper, Co-founder and CEO of Inflazome Ltd, commented: “We’re delighted to welcome these renowned and accomplished experts to Inflazome. Prof. Balkwill’s knowledge of translating cancer biology and its links to inflammation will progress the development of anti-inflammatory drugs in the field of oncology. Dr. Morris’s and Dr. Patel’s experience and guidance will be instrumental as we transition Inflazome’s research programmes into clinical development and expand our pipeline of novel inflammasome inhibitors. These appointments significantly augment Inflazome’s senior advisory team and their contributions will help us towards achieving our mission; improving lives by delivering new medicines that stop harmful inflammation.”

Prof. Frances Balkwill, OBE FMedSci, commented: “I’m excited to join Inflazome’s Scientific Advisory Board and contribute to their outstanding scientific underpinnings. Understanding the role inflammasomes play in driving tumour progression could deliver innovative cancer therapies from Inflazome’s portfolio of potent and selective NLRP3 inhibitors.”

Dr. David Morris, Novartis Venture Fund, commented: “Inflazome is attacking harmful inflammation which causes many of our most challenging medical conditions today. I‘m pleased to join the Scientific Advisory Board to help steer the company forward to develop potential new and necessary treatments for patients.”

Dr. Dhavalkumar Patel, Executive Vice President and Chief Scientific Officer, UCB, commented: “I’m excited to join Inflazome’s Board of Directors to help guide Inflazome’s pipeline of drugs that target aberrant, innate immune system activation. The company has an advanced portfolio of potent drug leads and drug candidates, led by an accomplished management team with a wide range of expertise and capabilities.”

 

About Prof. Frances Balkwill

Prof. Frances Balkwill OBE FMedSci is Professor of Cancer Biology at Barts Cancer Institute, Queen Mary University of London where she leads the Centre for Cancer and Inflammation. She studies the links between cancer and inflammation, with a special interest in translating knowledge of cancer biology into new biological treatments for cancer, the role that inflammatory cytokines play in cancer promotion and novel ways of modelling the human tumour microenvironment. Prof. Balkwill runs a research centre of approximately 30 scientists, postgraduate students and clinicians. She is an author on 250+ scientific papers and reviews and has written and edited a number of academic books on her subject. In 2006, she was made a Fellow of the Academy of Medical Sciences and has served on its Council.

About Dr. David Morris

Dr. Morris joined Novartis in Basel in 2009 and has held multiple positions within the organization including the Development Franchise head for Respiratory and Primary Care. His team were responsible for the clinical development, regulatory approvals and lifecycle management of multiple Novartis medications including new treatments for serious respiratory diseases (Chronic obstructive pulmonary disease (COPD), asthma, pulmonary hypertension) and diabetes. He also held overall responsibility for global clinical operations, quantitative sciences, digital innovation, development informatics, and global clinical research capabilities development for Novartis Global Drug Development. In September 2016, he transitioned to the Novartis Venture Fund to leverage his basic and clinical scientific background and operational experience to better speed the discovery and development of new medicines by working closely with external entrepreneurs and venture backed start-ups.

About Dr. Dhavalkumar Patel

Dr. Dhavalkumar Patel joins Inflazome as an Independent Director on the Board of Directors. Dr Patel brings extensive experience in drug discovery in industry. During a 10 year career in Novartis, he led Research in Europe and the Autoimmunity, Transplantation and Inflammation Disease Area which contributed to the registration of several leading drugs in multiple indications. Dr Patel has most recently been appointed Executive Vice President and Chief Scientific Officer, UCB, the global biopharmaceutical company.

 

Members of Inflazome’s Board of Directors include:

•                Dr. Manus Rogan, Chair, Managing Partner, Fountain Healthcare Partners

•                Dr. Matt Cooper, Co-founder & Chief Executive Officer

•                Florent Gros,  Managing Director, Novartis Venture Fund

•                Prof. Luke O’Neill, Co-founder & Chief Scientific Officer

•                Dr. Dhavalkumar Patel, Independent Director
 

Members of Inflazome’s Scientific Advisory Board include:

•                Prof. Luke O’Neill, Trinity College Dublin

•                Dr. Douglas Golenbock, University of Massachusetts Medical School

•                Prof. Veit Hornung, Ludwig Maximilian University of Munich

•                Prof. Mihai G. Netea, Nijmegen University

•                Prof. Frances Balkwill, Queen Mary University of London

•                Dr. David Morris, Novartis Venture Fund

 

About Inflazome

Utilising the scientific expertise of our founders and advisors, Inflazome is leading the way in developing orally available drugs to address clinical unmet needs in inflammatory diseases by targeting the inflammasome, which is now thought to drive many chronic inflammatory conditions.

Headquartered in Dublin, Ireland, Inflazome was founded by leading academics Prof. Matt Cooper, The University of Queensland (Australia) and Prof. Luke O’Neill Trinity College Dublin (Ireland), following a highly productive joint collaboration. inflazome.com

 

Founding investors are Fountain Healthcare Partners (Dublin, Ireland) and Novartis Venture Fund (Basel, Switzerland).

About Fountain Healthcare Partners

Fountain Healthcare Partners is a life science focused venture capital fund with €176 million ($200 million) under management. Within the life science sector, specific areas of interest to Fountain include specialty pharma, medical devices, biotechnology and diagnostics. The firm deploys the majority of its capital in Europe, with the balance in the United States. Fountain’s main office is in Dublin, Ireland, with a second office in New York. fh-partners.com  

About The Novartis Venture Fund

The Novartis Venture Fund (NVF) manages over $700 million in committed capital. NVF invests in companies that have the potential to change a core therapeutic field or explore new business areas that will be critical to patient care. NVF’s primary interest is in the development of novel therapeutics and platforms as well as medical devices, diagnostics, and delivery systems. The Funds invest for financial objectives at all stages, but prefers to invest in the early-stages of company development. With investment professionals located in Basel, Switzerland and Cambridge, MA the team has extensive experience in pharmaceutical R&D and venture capital. nvfund.com 

Contacts:
Dr. Jeremy Skillington | VP Business Development | j.skillington@inflazome.com | +353 1 679 8591
Ruth Neale | Communications and Outreach | r.neale@inflazome.com | +44 1223 751549

Inflazome’s Chief Scientific Officer ranked in the top 1% of the world’s Immunologists

Inflazome’s Chief Scientific Officer ranked in the top 1% of the world’s Immunologists

Dublin, Ireland – 24 November, 2017 -  Inflazome’s Co-Founder and Chief Scientific Officer, Professor Luke O’Neill, has been ranked in the top 1% of highly cited immunology researchers by Clarivate Analytics, a global leader in insights and analytics. Prof. O’Neill’s academic group at Trinity College Dublin works on the molecular basis of innate immunity and inflammation.

Clarivate Analytics list for 2017 also includes Inflazome Scientific Advisory Board member Professor Veit Hornung, who also works in immunology based at Ludwig-Maximilians University, Munich, Germany.

Highly Cited Researchers are leading the way in solving the world’s biggest challenges, states Clarivate Analytics. The list is based off data that the company collects from its “Web of Science” platform, which is a database of over 33,000 scientific journals. The list is composed of over 3,300 researchers who have a high number of published papers which appear in the top 1% of most-cited in their research area over the last 11 years. The full 2017 list can be found here.

Inflazome Expands Management Team

Inflazome Expands Management Team

Inflazome announces the appointment of two industry leaders with extensive drug discovery and development expertise to its Management Team

Inflazome Closes Series A Financing

Inflazome Closes Series A Financing

Inflazome raises $17m from Novartis Venture Fund and Fountain Healthcare Partners to develop treatments for chronic inflammatory diseases.